The Effect of Collagen on Human Health

Studies showed that Bioactive Collagen Peptides aids in young physically adults with knee pain:-

In Summary:

“Abnormal pressure due to sudden twisting movements or changes in direction can potentially injure joints, tendons and ligaments.”

1. In physically active subjects, pain, injury and diseases of the musculoskeletal system are a relatively common complication causing impaired performance and reduced training gain. In addition, in younger years, abnormal pressure due to sudden twisting movements or changes in direction can potentially injure joints, tendons and ligaments.
2. Acute degradation of connective tissue in tendons, cartilages and ligaments must be repaired, which is associated with a cascade of inflammation and pain. Long-term biomechanical stress, high loading impact on the joint or sudden unphysiological movements (e.g., rapid stopping or changes of direction) can lead to acute or chronic overuse of the joint and, if not treated, to injuries or chronic degenerative diseases.
3. The cause regardless of whether muscles, tendons or cartilage tissue are affected—is a disproportion between load and load tolerance of the tissue. Excessive training, inadequate recovery periods, incorrect techniques or movement sequences as well as constant competitive stress can be extrinsic factors that potentially increase the incidence of stress-induced injuries
   in every age group

“Due to their low molecular weight and the high proportion of proline and hydroxyproline, collagen peptides show a high resistance to intestinal digestion and higher transport efficiency.”

1. Current data from preclinical studies indicate that collagen peptides have a particularly high absorption rate. Due to their low molecular weight and the high proportion of proline and hydroxyproline, collagen peptides show a high resistance to intestinal digestion and higher transport efficiency.
2. It has been demonstrated that collagen-derived peptides accumulate in the cartilage tissue, where they can stimulate the chondrocytes to synthesize cartilage extracellular matrix molecules and counteract progressive tissue degeneration.
3. This investigation was designed as a single-center, prospective, randomized, doubleblind, placebo-controlled trial conducted at the University of Freiburg, Germany. In total, 218 healthy physically active (sports activities of more than 3 h a week) men and women aged between 18 and 30 years with activity-related functional knee joint pain.
4. daily dose of 5 g. The powders had to be dissolved in 250 mL of water at room temperature and ingested once daily for 12 weeks.
5. Half of the athletes had knee joint pain during and after physical activity. Forty-four percent reported knee pain in both knees, while 56% suffered from knee pain either in the left (25%) or
   right (31%) knee. According to the medical history, endurance exercises, team sports and fitness training were the main activities leading to knee pain.

“Young physically active men and women age 18-30 years old showed that the intake of 5 g of specific collagen peptides per day for twelve weeks can significantly reduce the intensity of activity-related knee joint pain”

1. The current study with young physically active men and women showed that the intake of 5 g of specific collagen peptides per day for twelve weeks can significantly reduce the intensity of activity-related knee joint pain assessed by the participants compared with placebo. These findings were confirmed by the physician’s assessment.
2. To date, there is only a limited number of intervention studies that investigated the pain-relieving effect of collagen peptides on functional joint complaints. In a pilot study, the oral intake of collagen peptides resulted in an improvement in pain symptoms in stress-induced joint complaints.
3. Continuous stress or an insufficient recovery phase promotes the development of pain under resting conditions.
4. In the present study, some subjects initially described instability of the knee joint. In these cases, improved joint stability was observed after 12 weeks of intervention with collagen peptides.

“Tendons and ligaments are important structures of the musculoskeletal system that determine the mobility and stability of the joints.”

1. Tendons and ligaments are important structures of the musculoskeletal system that determine the mobility and stability of the joints. Excessive mobility (hypermobility) due to increased laxity of the ligaments is associated with an increased risk of injury and osteoarthritis.
2. The influence of collagen peptides on the structure and functionality of tendons and ligaments is, therefore, a potential approach to alleviate stress-related knee joint problems.
3. In addition, the Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaires—a specific, reliable and valid clinical measure of Achilles tendinopathy—showed a significant
   improvement in the areas of pain, function in daily life and physical activity through the intake of specific collagen peptides.